重组人成纤维细胞生长因子-19 rhFGF-19
Recombinant Human Fibroblast Growth Factor-19
品牌：
ScienCell
货号：
104-19
价格：
$93.00
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Fibroblast growth factor 19 (FGF-19) belongs to the large FGF family which has at least 23 members. However, FGF-19, along with FGF-21 and FGF-23, belongs to a subfamily of atypical FGFs where it lacks a conventional heparin-binding motif. Therefore, its signal transduction is mediated by the cofactor ?Klotho when interacting with FGFRs 1c, 2c and 3c. Interestingly, FGF-19 can interact directly with FGFR4 in absence of ?Klotho. FGF-19 regulates metabolic processes including bile acid, lipid and glucose homeostasis, as well as hepatocyte proliferation. Administration of recombinant FGF-19 to mice decreased cholesterol 7-alpha-hydroxylase (CYP7A1) expression, the rate limiting step in bile acid biosynthesis pathway in the liver.
| 货号 | 104-19 |
| 产地 | 美国 |
| 缩写 | rhFGF-19 |
| 规格 | 5ug |
| 用途 | 科研 |
| 储存 | -20度 |
| 运输 | 干冰 |
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