3D肾小管上皮细胞形成试剂盒 3D-RTF
3D Renal Tubule Formation Kit
品牌：
ScienCell
货号：
3D-4110
价格：
$1054
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The human kidney is frequently exposed to drugs and toxic compounds, which can result in nephrotoxicity. A drug’s uptake and clearance from the kidney largely relies on a subset of membrane transporters such as organic anion transporters (OAT) 1/3, organic cation transporter (OCT) 2, and multidrug and toxin extrusion proteins (MATE) 1/2. In 2D monolayer culture, primary renal epithelial cells rapidly lose the expression of OAT1/3, OCT2, and MATE1/2, limiting the accurate redictability of a drug’s effect [1]. ScienCell has developed a 3D renal tubule formation kit (3D-RTF) using human primary renal cortical epithelial cells isolated from normal adult kidney tissue, which are then embedded in Collagen I extracellular matrix. We demonstrated that renal tubule structures are formed in a robust and reproducible manner in a 3D collagenembedded model using the 3D-RTF. 3D cultured renal epithelial cells had elevated expression levels of xenobiotic transporters such as OAT1/3, and MATE1/2 (see Figure 1 and 2). The 3DRTF provides a useful in vitro tool for accurately predicting a drug’s effect on kidney function.
| 货号 | 3D-4110 |
| 产地 | 美国 |
| 缩写 | 3D-RTF |
| 规格 | Kit |
| 用途 | 科研 |
| 储存 | -20度 |
| 运输 | 干冰 |
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细胞检测试剂盒
细胞检测试剂盒
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