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GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF acts as a prosurvival factor and activates effector functions of granulocytes, monocytes/macrophages, and eosinophils. It promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity. The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four αundled ?-helices. Mature mouse GM-CSF shares 49% - 54% amino acid sequence identity with canine, feline, human, and porcine GM-CSF and 69% with rat GM-CSF. The activity of GM-CSF is species specific between human and mouse. Mouse GM-CSF is only weakly active on rat cells, although rat GM-CSF is fully active on mouse cells.
货号 | 122-03 |
产地 | 美国 |
缩写 | rmGM-CSF |
规格 | 5ug |
用途 | 科研 |
储存 | -20度 |
运输 | 干冰 |
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小鼠
小鼠
货号 | 产品名称 | 规格 | 价格 | 指令 | |
122-03 | 重组鼠粒细胞巨噬细胞集落刺激因子 rmGM-CSF | 5ug | $95 | + | |
123-01 | 重组鼠肿瘤坏死因子-alpha rmTNF-α | 5ug | $95 | + | |
123-07 | 重组小鼠白血病抵制因子 rMuLIF | 5ug | $95 | + | |
124-02 | 重组鼠成纤维细胞生长因子 rmbFGF | 10ug | $95 | + | |
124-07 | 重组鼠成纤维细胞生长因子-7 rmbFGF-7 | 2ug | $95 | + | |
125-04 | 重组鼠表皮生长因子 rmEGF | 100 μg | $95 | + | |
125-06 | 重组鼠血管内皮生长因子120 rmVEGF120 | 2 μg | $95 | + | |
125-07 | 重组鼠血管内皮生长因子165 rMuVEGF165 | 2 μg | $95 | + | |
128-09 | 重组鼠头蛋白 rmNOGGIN | 5 μg | $95 | + | |
221-16 | 重组鼠CXCL16 rmCXCL16 | 5 μg | $95 | + |