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IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF
binding protein present in the plasma of human and animals and it is
also found in α-granules of platelets. In addition to its ability to
modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory
effects on follicle stimulating hormone (FSH) activity. Decreased plasma
levels of IGF-BP3 often results in dwarfism, whereas elevated levels of
IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in
fibroblasts is stimulated by mitogenic growth factors such as Bombesin,
Vasopressin, PDGF, and EGF.
货号 | 105-01B3 |
产地 | 美国 |
缩写 | rhIGF-BP3 |
规格 | 5 μg |
用途 | 科研 |
储存 | -20 |
运输 | 干冰 |
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