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Oncostatin M (OSM) is a growth and differentiation factor that
participates in the regulation of neurogenesis, osteogenesis and
hematopoiesis. Produced by activated T cells, monocytes and Kaposi's
sarcoma cells, OSH can exert both stimulatory and inhibitory effects on
cell proliferation. It stimulates the proliferation of fibroblasts,
smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth
of some normal and tumor cell lines. It also promotes cytokine release
(e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the
expression of low-density lipoprotein receptor in hepatoma cells. OSM
share several structural and functional characteristics with LIF, IL-6,
and CNTF. Human OSM is active on murine cells.
货号 | 103-08T |
产地 | 美国 |
缩写 | rhOSM 209aa |
规格 | 2 μg |
用途 | 科研 |
储存 | -20度 |
运输 | 干冰 |
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