重组人肿瘤坏死因子-alpha Variant rhTNF-α variant
Recombinant Human Tumor Necrosis Factor-alpha Variant
品牌：
ScienCell
货号：
103-01v
价格：
$95
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The clinical use of the potent antitumor activity of TNF-α has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-α55 but not to the murine TNF-α75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-α55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo.
| 货号 | 103-01v |
| 产地 | 美国 |
| 缩写 | rhTNF-α variant |
| 规格 | 10ug |
| 用途 | 科研 |
| 储存 | -20度 |
| 运输 | 干冰 |
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